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Prioritize your tasks with Microsoft To Do. Locate messages, people, and documents. The expression of IL is minimal in unstimulated tissues and seems to require triggering by commensal or pathogenic flora.
Extensive IL locus remodeling is observed in monocytes upon stimulation of TLR or Fc receptor pathways. IL is a cytokine with multiple, pleiotropic , effects in immunoregulation and inflammation.
It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production.
Over time a more nuanced picture of IL's function has emerged as treatment of tumor bearing mice has been shown to inhibit tumor metastasis.
Expression of IL from transfected tumor cell lines   in IL transgenic mice  or dosing with IL leads to control of primary tumor growth and decreased metastatic burden.
A study in mice has shown that IL is also produced by mast cells , counteracting the inflammatory effect that these cells have at the site of an allergic reaction.
It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells; however, it is also stimulatory towards certain T cells Th2 and mast cells and stimulates B cell maturation and antibody production.
IL checks the inducible form of Cyclo-oxygenase, Cyclo-oxygenase-2 COX Lack of IL has been shown to cause COX activation and resultant Thromboxane receptor activation to cause vascular endothelial and cardiac dysfunctions in mice.
Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age. IL is linked to the myokines , as exercise provokes an increase in circulating levels of IL-1ra, IL, and sTNF-R, suggesting that physical exercise fosters an environment of anti-inflammatory cytokines.
Lower levels of IL have been observed in individuals diagnosed with multiple sclerosis when compared to healthy individuals. In melanoma cell lines, IL modulates the surface expression of NKG2D ligands.
Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Due to the data, thousands of patients suffering from a variety of autoimmune diseases were treated with recombinant human IL rHuIL in clinical trials.
Contrary to expectations, rHuIL treatment did not significantly impact disease in patients with Crohn's disease.
Further to these data, a Phase I immunoncology clinical trial is currently being conducted to assess the therapeutic capacity of PEGylated recombinant human IL PEG-rHuIL, AM As of [update] AM aka pegilodecakin is in phase 3 clinical trials.
IL has been shown to interact with Interleukin 10 receptor, alpha subunit. The receptor complex for IL also requires the IL10R2 chain to initiate signalling.
This ligand—receptor combination is found in birds and frogs, and is also likely to exist in bony fish.
From Wikipedia, the free encyclopedia. IL10 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ILK , 1INR , 1J7V , 1LK3 , 1Y6K , 2ILK , 2H24 Identifiers Aliases IL10 , CSIF, GVHDS, IL, IL10A, TGIF, interleukin 10 External IDs OMIM: MGI: HomoloGene: GeneCards: IL10 Gene location Human Chr.
Chromosome 1 human . National Center for Biotechnology Information, U. National Library of Medicine. Immunological Reviews.
Annual Review of Immunology. Nature Medicine. David November Brain, Behavior, and Immunity. PLOS ONE. Nature Reviews.
European Journal of Immunology. Journal of Immunology. The EMBO Journal. Proceedings of the National Academy of Sciences of the United States of America.
The Journal of Experimental Medicine. FASEB Journal. Journal of Neuroimmunology. Infection and Immunity.
International Journal of Cancer. Journal of Immunotherapy. Cancer Research. Cancer Cell. Nature Immunology. Experimental Gerontology.
European Journal of Applied Physiology. The Journal of Physiology. Scandinavian Journal of Immunology.
Immunology and Cell Biology. Clinical Gastroenterology and Hepatology. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group".
Crohn's Disease IL Cooperative Study Group". Crohn's Disease Study Group". The Journal of Rheumatology.
Archives of Dermatology. ASCO Meeting Abstracts. The Journal of Biological Chemistry. Acta Crystallographica Section D.
European Journal of Biochemistry. Bortesi L, Rossato M, Schuster F, Raven N, Stadlmann J, Avesani L, Falorni A, Bazzoni F, Bock R, Schillberg S, Pezzotti M March BMC Biotechnology.
Zhu H, Wang Z, Yu J, Yang X, He F, Liu Z, Che F, Chen X, Ren H, Hong M, Wang J March Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A Girndt M Blood Purification.
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